Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States. Electronic address: gpiazza@bwh.harvard.edu. Section of Cardiology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, United States. Department of Cardiology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States. Amgen Inc., Thousand Oaks, CA, United States. The University of Texas at Austin Dell School of Medicine, Austin, TX, United States.